Clinical Trials

AREF provides the oversight, staff and support for the implementation of clinical studies that keep our physicians on the leading–edge of medicine.

These studies provide patients the latest technological advancements in pharmaceuticals and medical devices and aid both physicians and patients in making better informed treatment decisions. These studies impact the clinical outcomes for patients as our findings are shared with clinicians throughout the world.

Current Clinical Trials At Andrews Research & Education Foundation:

Name ArthroFlex
Description Use of ArthroFlex™ for Reconstruction of Massive or Recurrent Rotator Cuff Tears to determine if outcomes associated with ArthroFlex are equal to or better than traditional rotator cuff reconstruction of massive or recurrent tears.
Investigator Charles Roth, M.D. and Christopher O’Grady, M.D.
Discipline Orthopaedic
Target Disease Male and Female 18 and older with Rotator Cuff Tears

Name Dynasplint
Description Outcomes Following Dynamic Splinting and/or Physical Therapy for Patients with Adhesive Capsulitis
Investigator Joshua Hackel, M.D.
Discipline Orthopaedics
Target Disease Frozen Shoulder

Name In–House Research
Description Prospective study for the incidence of phrenic nerve palsy during a posterior approach to the brachial plexus using ultrasound guidance when performing regional anesthesia prior to scheduled outpatient shoulder surgery
Investigator Gregory V. Hickman, M.D.
Discipline Anesthesia / Pre–surgical anesthesia
Target Disease Analgesia

Name Roche
Description A clinical outcomes study to evaluate the effects of IL-6 receptor blockade with tocilizumab (TCZ) in comparison with etanercept (ETA) on the rate of cardiovascular events in patients with moderate to severe rheumatoid arthritis (RA)
Investigator Rachel Brown, M.D.
Discipline Orthopaedics
Target Disease Rheumatoid arthritis

Name SpeedGel
Description The Effect of SpeedGel Rx on Postsurgical Pain, and the use of Narcotics
Investigator James Andrews, M.D.
Discipline Orthopaedics
Target Disease Post ACL surgical reconstruction pain

Name Zimmer Denovo
Description A Stratified, Post-Market Study of DeNovo® NT for Treatment of Femoral and Patellar Articular Cartilage Lesions of the Knee
Investigator Charles A. Roth, M.D.
Discipline Orthopaedics
Target Disease Femoral and Articular Cartilage Defects in the Knee

Name EmCyte
Description Efficacy of bone marrow aspirate concentrate compared with platelet rich plasma for the treatment of symptomatic knee osteoarthritis in a retired professional athlete population: A randomized, controlled clinical trial.
Investigator Joshua G. Hackel, M.D.
Discipline Orthopaedics
Target Disease Knee osteoarthritis

Name OrthoCor
Description A prospective, double blind, placebo controlled study on patient satisfaction outcomes with the use of an Orthocor PEMF treatment for osteoarthritis
Investigator G. Daxton Steele, M.D. & Joshua Hackel, M.D.
Discipline Orthopaedics
Target Disease Knee osteoarthritis